Pros and cons of a single supermemo collection
There is no good and right about having one single collection or several for SuperMemo. You may decide when it is best to start a new collection, merge collections, or transfer branches between different collections according to many factors and current needs.
Interleaving
Video/audio repetitions break the flow
Stats
Averages may be not representative
Analytics
Duplicates
Backup
Time investment
Registries
Searches
Collection repairs
Collection parameters
Same collection parameters for different difficulties
Final Drill
Having multiple collections make the selective final drill very accesible, as you can turn on/off the finall drill for each collection. For instance I could turn it on for language learning collections. Having a single collection makes the finall drill a everything or nothing choice. There is a word-around by creating subset reviews from the drill queue (video).
Priorities
Requires more precision for prioritization